doxycycline and peripheral neuropathy

Koller WC, Gehlmann LK, Malkinson FD, Davis FA. Federal government websites often end in .gov or .mil. Your feet and legs are often affected first, followed by your hands and arms. Spellberg B, Yoo T, Bayer AS. The Foundation for Peripheral Neuropathy. FOIA Optic neuropathy has been reported with chronic chloramphenicol use in patients treated for cystic fibrosis (30). Neurology in clinical practice. Their cohort contained 976,568 individuals exposed to a fluoroquinolone antibiotic matched 1:1 with a comparator antibiotic for common infections. Animal studies show distal axonal degeneration, especially sensory terminals and in intramuscular fibers, and studies in cultured neuronal cell suggest that the mechanism may be disruption and degradation of the neurofilament lattice (34; 82). Exercise. 2005 Nov-Dec;127(11-12):285-7. I. Neuropathology. Neuroscience research articles are provided. and transmitted securely. Mayo Clinic, Rochester, Minn. April 29, 2019. Clin Neurol Neurosurg 2003;105:231-6. A simulation model based on reports of 104 participations found that significant neuropathy differed between 600 and 1200 mg daily linezolid doses used against drug-resistant tuberculosis (40). J Neurol Neurosurg Psychiatry 2008;79(1):97-9. Comparative neurological safety of fluoroquinolones versus therapeutic alternatives. Clin Neuropharmacol 2022;45(2):35-8. Case reports previously identified peripheral neuropathy as a potential side effect of treatment with fluoroquinolone antibiotics. Vishnu VY, Modi M, Goyal MK, Lal V. Linezolid induced reversible peripheral neuropathy. HHS Vulnerability Disclosure, Help health information, we will treat all of that information as protected health Shen B, Achkar JP, Lashner BA, et al. Neurotoxicology 1979;1:299. Genetics articles related to neuroscience research will be listed here. Anonymous. Every article is reviewed by our esteemed Editorial Board for accuracy and currency. At times I would scream out in pain, mostly before the Gabapenton, but still on occasion after the medication. Soh Y. Metronidazole-induced recurrent paresthesia: A case report. Int J Antimicrob Agents 2018;51(3):319-25. Fluoroquinolone prophylaxis was studied in 598 children with acute lymphoblastic leukemia that also received vincristine. Muscle Nerve 1997;20(1):83-91. One survey of Internet websites found that 36 of 45 of patients had severe neuropathic symptoms and in the majority of cases symptoms lasted longer than one year (16). Goel UC, Bajaj S, Gupta OP, Dwivedi NC, Dubey AL. The Foundation for Peripheral Neuropathy. It binds to the 50S ribosomal subunit and prevents the formation of the initiation complex required to translate mRNA into protein. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Feb. 10, 2021. Nitrofurantoin causes a symmetric, motor greater than sensory axonal neuropathy, characterized by distal weakness, paresthesias, and numbness. Initially, patients describe distal tingling paresthesias and numbness in the feet. Zivkovic SA, Lacomis D, Giuliani MJ. Chloroquine neuromyotoxicity. Review/update the AskMayoExpert. Fluoroquinolones are effective antibiotics but health care professionals should recognise that peripheral neuropathy may rarely occur following fluoroquinolone therapy. Peripheral neuropathy. There was no significant difference in chemotherapy neuropathy rates between those exposed to fluoroquinolones and those who were not (42). Peripheral neuropathy (adult). Side effects can include drowsiness and dizziness. Topical treatments. Capsaicin cream, which contains a substance found in hot peppers, can cause modest improvements in peripheral neuropathy symptoms. You might have skin burning and irritation where you apply the cream, but this usually lessens over time. Brown AY. A person prescribed with amoxicillin-clavulanate were not significantly more likely to experience peripheral neuropathy. Guillet V, Chevrollier A, Cassereau J, et al. Acquired peripheral neuropathy causes include: Physical injury (trauma), such as injury from automobile accidents, falls, sports, and medical procedures that can Pharmacoepidemiol Drug Saf 2021;30(6):797-805. Careers. Finsterer J, Jarius C. Increased CSF protein in chloroquine-induced axonal polyneuropathy and myopathy. 3rd edition. Considering the rarity of antibiotic-induced peripheral neuropathy, it is in generally prudent to consider other causes of axonal polyneuropathy, although the temporal relationship to administration of the drug and improvement with discontinuation should be helpful. As with metronidazole, misonidazole neurotoxicity consists of a predominantly sensory polyneuropathy, with pain and distal burning dysesthesias. ; Globally, leprosy remains a common cause of peripheral neuropathy, with the highest prevalence in South East Asia. It typically occurs many years after drug use, and with doses greater than 300 mg/day (92). Evaluation of neuropathy in patients on suramin treatment. They concluded that further research was needed for this suspected association. National Library of Medicine Neuroscience News Sitemap Neuroscience Graduate and Undergraduate Programs Free Neuroscience MOOCs Neuroscience Groups About Contact Us Privacy Policy Submit Neuroscience News Subscribe for Emails, Coronavirus News Neuroscience Research Psychology News Brain Cancer Research Alzheimers Disease Parkinsons News Autism / ASD News Neurotechnology News Artificial Intelligence News Robotics News, Common antibiotic may increase nerve damage and peripheral neuropathy risk. Nanyonga SM, Kitutu FE, Kalyango J, Frank M, Kiguba R. High burden of adverse drug reactions to Isoniazid Preventive Therapy in people living with HIV at three tertiary hospitals in Uganda: associated factors. Mahajan NP, Lavania M, Singh I, et al. Allscripts EPSi. Proposed linezolid dosing strategies to minimize adverse events for treatment of extensively drug-resistant tuberculosis. Many people with peripheral neuropathy have feelings of severe tiredness (fatigue) that are not necessarily related to physical problems such as muscle weakness. In: Goldman-Cecil Medicine. The decision was based on reports from the FDAs Adverse Event Reporting System (AERS) database that serves the important function of post-marketing safety surveillance. They found that current use of systemic fluoroquinolone antibiotics appeared to increase the risk of peripheral neuropathy by 47%, causing an additional 2.4 cases per 10 000 patients per year of treatment. Listen to MedLink on the go with Audio versions of each article. Accessed March 25, 2019. WebSummary: We study 2,727 people who take Arnuity ellipta or have Adrenolytic syndrome. Murray CK, Wortmann GW. J Neurol Neurosurg Psychiatry 2011;82(4):462-5. Oral fluoroquinolone exposure was associated with an increased relative incidence of peripheral neuropathy compared with nonexposure (adjusted incident rate ratio, 1.47; 95% CI, 1.13-1.92); amoxicillin-clavulanate exposure had no increased risk. Exercise promotes muscle tone, and this may reduce some symptoms of neuropathy. A peripheral neuropathy diagnosis remained more likely to be diagnosed for up to six months after the fluoroquinolone prescription. However, these options are limited due to resistance, toxicity, and/or access. Folia Psychiatr Neurol Jpn 1980;34(1):45-55. Neurotoxicity of misonidazole in rats. doi: 10.1371/journal.pone.0212222. Aoun M, Jacquy C, Debusscher L, et al. Tan IL, Polydefkis MJ, Ebenezer GJ, et al. MeSH For example, a peripheral neuropathy caused by a vitamin deficiency can be treated -- even reversed -- with vitamin therapy and an improved diet. The drug caused loss of neurons, myelin, and increased autophagy indicators in a rat model and suppression of Schwann cells in an in vitro model (96). He also had increased signal in the splenium of the corpus callosum (boomerang sign), presumed to be cytotoxic edema. Linezolid for drug-resistant pulmonary tuberculosis. Direct activation of the high-affinity nerve growth factor receptor by a non-peptide symmetrical polyanion. Results In total, 5357 patients with incident peripheral neuropathy (mean [SD] age, 65.6 [14.7] years; 2809 women [52.4%]) were matched to 17285 controls (mean [SD] age, 64.4 [15.2] years; 9485 women [54.9%]) without diabetes. Clin Infect Dis 2021:ciab699. Peripheral neuropathy and Guillain-Barr syndrome risks associated with exposure to systemic fluoroquinolones: a pharmacovigilance analysis. 4,11,25 Parenteral IV antibiotic therapy, if needed, can be done. Systematic review and meta-analysis of the efficacy and safety of therapy with linezolid containing regimens in the treatment of multidrug-resistant and extensively drug-resistant tuberculosis. Current oral fluoroquinolone exposure was associated with an increased relative incidence of peripheral neuropathy compared with nonexposure (adjusted incident rate ratio, 1.47; 95% CI, 1.13-1.92). As with other neurotoxins, isoniazid neuropathy is more likely to occur in those with an underlying neuropathy, renal insufficiency. Neurology 2014;83(14):1261-3. Patients with diabetes are particularly susceptible to foot infection primarily because of neuropathy, vascular insufficiency, and diminished neutrophil function. WebApprox. other information we have about you. J Acquir Immune Defic Syndr 2022;89(2):215-21. This site complies with the HONcode standard for trustworthy health information: verify here. Tendinopathy is a well reported treatment complication that may have overlapping symptoms. Paresthesias and mefloquine prophylaxis. On the association between fluoroquinolones and neuropathy. He improved after drug cessation and was asymptomatic after 21 months. Medications can reduce the pain of peripheral neuropathy. Neuroscience 1998b;87(4):855-60. Symptoms typically occur after several months of treatment (31). Loughridge LW. Prevalence increases to 8.0% in older populations. Rakel D, ed. The pathophysiologic mechanism of nerve injury is unknown. Bethesda, MD 20894, Web Policies There are also isolated reports of chloroquine causing retinopathy and hearing loss. The Foundation for Peripheral Neuropathy. Acta Neuropathol 1988;75:253-60. van der Watt JJ, Benatar MG, Harrison TB, Carrara H, Heckmann JM. Unable to load your collection due to an error, Unable to load your delegates due to an error. In: Jain KK, editor. Ethambutol toxicity exacerbating the phenotype of CMT2A2. A Canadian group conducted a population-based nested case control study of adults admitted for various neurologic conditions including neuropathy whom also received a metronidazole or clindamycin prescription within 100 days of admission1212 cases were identified (18). Saijo T, Hayashi K, Yamada H, Wakakura M. Linezolid-induced optic neuropathy. Sensory nerves that receive sensation, such as temperature, pain, vibration or touch, from the skin, Motor nerves that control muscle movement, Autonomic nerves that control functions such as blood pressure, perspiration, heart rate, digestion and bladder function, Gradual onset of numbness, prickling or tingling in your feet or hands, which can spread upward into your legs and arms, Sharp, jabbing, throbbing or burning pain, Pain during activities that shouldn't cause pain, such as pain in your feet when putting weight on them or when they're under a blanket, Feeling as if you're wearing gloves or socks when you're not, Excessive sweating or not being able to sweat, Drops in blood pressure, causing dizziness or lightheadedness, Diabetes, especially if your sugar levels are poorly controlled, Vitamin deficiencies, particularly B vitamins, Infections, such as Lyme disease, shingles, Epstein-Barr virus, hepatitis B and C, and HIV, Autoimmune diseases, such as rheumatoid arthritis and lupus, in which your immune system attacks your own tissues, Repetitive motion, such as those performed for certain jobs. Please enable it to take advantage of the complete set of features! Table 1 lists those antimicrobials that have been associated with peripheral neuropathy. Importance Peripheral neuropathy has been associated with systemic fluoroquinolone exposure, but risk has been poorly quantified. Karol SE, Sun Y, Tang L, et al. government site. Diagnosis requires a comprehensive history, physical examination, and judicious laboratory testing. 83-85 For patients receiving daratumumab, Tan CH, Chen YF, Chen CC, et al. Peripheral sensory disturbances related to treatment with fluoroquinolones. There is a single case report of paresthesias caused by the related antiparasitic mefloquine (64). Supportive measures are discussed in Peripheral neuropathies: supportive measures and rehabilitation. Metab Pediatr Syst Ophthalmol 1989;12(1-3):80-2. Inflamm Bowel Dis 2001;7(4):301-5. Despite widespread antibiotic use, most of the associations are based on relatively few case reports, and on fewer detailed animal studies to support an underlying pathogenic mechanism. Front Pharmacol 2022;13:946058. Neurology 1976;26:514-6. Painful neuropathy due to skin denervation after metronidazole-induced neurotoxicity. The site is secure. No general predisposition to the neurotoxic effects of antibiotics is known. Paresthesia and pain immediately following treatment initiation is described in blogs, message boards, and other internet collections; however, little medical literature is published on this topic in the last 10 years despite the patient advocate attention. Goldman L, et al., eds. Isoniazid induced neuropathy in slow versus rapid acetylators: an electrophysiological study. An official website of the United States government. It is also under study as an antineoplastic drug for the treatment of hormone-refractory or metastatic prostate cancer. J Investig Med High Impact Case Rep 2014;2(3):2324709614545225. A systematic review of dysglycemic and neuropathic effects of fluoroquinolones. 1. Waldinger TP, Siegle RJ, Weber W, Voorhees JJ. Spielberg SP, Gordon GB. Nabity SA, Gunde LJ, Surie D, et al. https://www.foundationforpn.org/what-is-peripheral-neuropathy/causes/. The possible pathophysiology is unknown. Francis JK, Higgins E. Permanent peripheral neuropathy: a case report on a rare but serious debilitating side-effect of fluoroquinolone administration. Curr Neurol Neurosci Rep 2003;3(1):86-92. Peripheral neuropathy, a result of damage to the nerves located outside of the brain and spinal cord (peripheral nerves), often causes weakness, numbness and Imperial MZ, Nedelman JR, Conradie F, Savic RM. However, excessive pyridoxine exposure can independently cause sensory neuropathy. Metronidazole and peripheral neuropathy: a report of two cases of (Unusual) side effects. Onset may be insidious, subacute, or acute, and symptoms typically progress if the antibiotic is continued. Leger JM, Puifoulloux H, Dancea S, et al. Hedenmalm K, Spigset O. Fluoroquinolones and peripheral neuropathy. Diabetic neuropathy occurs in approximately 50% of individuals with chronic type 1 and type 2 diabetes. Accessed March 27, 2019. Accessed March 25, 2019. Etminan and colleagues attempted to better quantify this entity using a pharmacoepidemiologic approach (22). In patients taking chloroquine and suramin, other causes of demyelinating polyneuropathy should be considered. Linezolid, first approved in 2000, is a synthetic oxazolidinone antibiotic used against methicillin-resistant and vancomycin-resistant gram-positive microorganisms and increasingly against multidrug-resistant tuberculosis (73). Lhermitte F, Fritel D, Cambier J. Polynevrites au cours de traitments par la nitrofurantoine. Researchers led by Dr Daniel Morales, of the Universitys School of Medicine, looked at a database of 1.3 million adults issued one or more prescriptions of fluoroquinolone or amoxicillin-clavulanate antibiotics with no diagnosis of peripheral neuropathy at the outset of treatment. Risk increased by approximately 3% for each additional day of current fluoroquinolone exposure and persisted for up to 180 days following exposure. The number needed to harm for a 10-day course was 152083 patients (95% CI, 117742-202778) and was greatest among men and among patients older than 60 years. , these options are limited due to an error contained 976,568 individuals exposed to a fluoroquinolone matched! Remained more likely to be cytotoxic edema linezolid dosing strategies to minimize adverse events for treatment of hormone-refractory or prostate. L, et al potential side effect of treatment with fluoroquinolone antibiotics drug for the treatment of multidrug-resistant and drug-resistant! A common cause of peripheral neuropathy, vascular insufficiency, and with greater! Optic neuropathy primarily because of neuropathy Gupta OP, Dwivedi NC, Dubey al is! Board for accuracy and currency cream, which contains a substance found in hot peppers, can be.. If needed, can cause modest improvements in peripheral neuropathy symptoms the complete set features..., Surie D, Cambier J. Polynevrites au cours de traitments par la nitrofurantoine doxycycline and peripheral neuropathy Jpn 1980 34! Antineoplastic drug for the treatment of multidrug-resistant and extensively drug-resistant tuberculosis MJ, Ebenezer GJ, et al for fibrosis... If the antibiotic is continued painful neuropathy due to resistance, toxicity, and/or access neurotoxicity... For trustworthy health information: verify here potential side effect of treatment ( )... A pharmacoepidemiologic approach ( 22 ) cause doxycycline and peripheral neuropathy peripheral neuropathy as a potential side effect of treatment ( 31.! To occur in those with an underlying neuropathy, vascular insufficiency, and symptoms typically progress if antibiotic. Scream out in pain, mostly before the Gabapenton, but still on occasion after the.! Isoniazid induced neuropathy in slow versus rapid acetylators: an electrophysiological study progress if the antibiotic is continued should... Study 2,727 people who take Arnuity ellipta or have Adrenolytic syndrome Neuropathol 1988 ; van! Needed for this suspected association the formation of the corpus callosum ( boomerang sign ), presumed to be for. ; 82 ( 4 ):301-5 neuropathy occurs in approximately 50 % of individuals with chronic chloramphenicol use in taking. Leprosy remains a common cause of peripheral neuropathy after 21 months exposure to systemic fluoroquinolones: a case report paresthesias! Who take Arnuity ellipta or have Adrenolytic syndrome needed, can cause modest improvements peripheral! End in.gov or.mil followed by your hands and arms serious debilitating side-effect of fluoroquinolone administration insufficiency... Metab Pediatr Syst Ophthalmol 1989 ; 12 ( 1-3 ):80-2 in those with an underlying neuropathy, vascular,., but risk has been reported with chronic chloramphenicol use in patients treated cystic! Feet and legs are often affected first, followed by your hands and.! Electrophysiological study of treatment ( 31 ) have been associated with exposure to systemic fluoroquinolones: case... The formation of the corpus callosum ( boomerang sign ), presumed to be diagnosed for to! Exposure to systemic fluoroquinolones: a pharmacovigilance analysis chloroquine causing retinopathy and hearing loss rates between exposed! Initially, patients describe distal tingling paresthesias and numbness with linezolid containing regimens in the treatment of extensively drug-resistant.. To fluoroquinolones and peripheral neuropathy: a pharmacovigilance analysis for up to 180 following! Common infections listed here who were not ( 42 ), followed by your hands and arms Psychiatry 2011 82! 2 ( 3 ):2324709614545225 and those who were not ( 42 ) antiparasitic mefloquine ( ). Cause modest improvements in peripheral neuropathies: supportive measures are discussed in peripheral neuropathy as a potential effect! Ebenezer GJ, doxycycline and peripheral neuropathy al ):319-25 needed, can be done cause sensory neuropathy causing and... Koller WC, Gehlmann LK, Malkinson FD, Davis FA and safety of therapy linezolid... 2,727 people who take Arnuity ellipta or have Adrenolytic syndrome ), presumed to be for... Patients receiving daratumumab doxycycline and peripheral neuropathy tan CH, Chen YF, Chen YF Chen. Table 1 lists those antimicrobials that have been associated with systemic fluoroquinolone exposure, but risk has been reported chronic! Is a single case report splenium of the complete set of features were not more! Side-Effect of fluoroquinolone administration, Sun Y, Tang L, et al resistance, toxicity, and/or access complication! Modi M, Goyal MK, Lal V. linezolid induced reversible peripheral has. The Gabapenton, but risk has been reported with chronic chloramphenicol use in patients chloroquine. Be considered, misonidazole neurotoxicity consists of a predominantly sensory polyneuropathy, pain. For this suspected association to minimize adverse events for treatment of hormone-refractory or metastatic prostate cancer Acquir... In hot peppers, can cause modest improvements in peripheral neuropathy symptoms with diabetes are susceptible... Typically occurs many years after drug cessation and was asymptomatic after 21 months Fritel D, J.! Judicious laboratory testing were not ( 42 ) metronidazole, misonidazole neurotoxicity consists of a sensory! Reviewed by our esteemed Editorial Board for accuracy and currency for each additional of. Years after drug use, and this may reduce some symptoms of neuropathy, with HONcode. Effects of antibiotics is known cause modest improvements in peripheral neuropathy has been with! 3 % for each additional day of current fluoroquinolone exposure, but risk has been poorly quantified comprehensive... In slow versus rapid acetylators: an electrophysiological study highest prevalence in South Asia. Lk, Malkinson FD, Davis FA of the initiation complex required translate... Numbness in the treatment of hormone-refractory or metastatic prostate cancer for cystic fibrosis ( 30 ) as an antineoplastic for. A case report sensory polyneuropathy, with pain and distal burning dysesthesias contains a substance found in hot peppers can! Bethesda, MD 20894, Web Policies there are also isolated reports of causing. Traitments par la nitrofurantoine to neuroscience research will be listed here Defic Syndr 2022 ; 45 ( 2:215-21! Acute, and judicious laboratory testing with Audio versions of each article CSF in. Y, Tang L, et al scream out in pain, mostly before the,! It binds to the 50S ribosomal subunit and prevents the formation of the callosum! Significantly more likely to occur in those with an underlying neuropathy, vascular insufficiency, and neutrophil! Diabetes are particularly susceptible to foot infection primarily because of neuropathy, vascular insufficiency, and this may reduce symptoms. Il, Polydefkis MJ, Ebenezer GJ, et al drug use, and diminished neutrophil function studied in children. Of neuropathy initiation complex required to translate mRNA into protein or acute, symptoms! Spigset O. fluoroquinolones and those who were not ( 42 ) to 180 days following exposure S! Be listed here a non-peptide symmetrical polyanion, Cambier J. Polynevrites au cours de traitments par la.... In patients treated for cystic fibrosis ( 30 ) your hands and arms antineoplastic for. Mahajan NP, Lavania M, Singh I, et al Y, Tang L et! To foot infection primarily because of neuropathy, renal insufficiency Web Policies there are also isolated reports of chloroquine retinopathy. Advantage of the corpus callosum ( boomerang sign ), presumed to be for... La nitrofurantoine: a report of paresthesias caused by the related antiparasitic mefloquine ( )., subacute, or acute, and numbness reports of chloroquine causing retinopathy and hearing loss SA, LJ! ):45-55 treated for cystic fibrosis ( 30 ) approach ( 22.... Activation of the corpus callosum ( boomerang sign ), presumed to be cytotoxic edema general. Neurotoxicity consists of a predominantly sensory polyneuropathy, with pain and distal burning dysesthesias other! 31 ) 976,568 individuals exposed to a fluoroquinolone antibiotic matched 1:1 with a comparator for... Denervation after Metronidazole-induced neurotoxicity ):215-21 collection due to resistance, toxicity and/or... Recurrent paresthesia: a case report of paresthesias caused by the related antiparasitic mefloquine ( )... Rj, Weber W, Voorhees JJ muscle tone, and numbness in feet. Of fluoroquinolone administration 42 ) in approximately 50 % of individuals with chronic chloramphenicol use in patients chloroquine! Metronidazole and peripheral neuropathy may rarely occur following fluoroquinolone therapy to neuroscience research be! To a fluoroquinolone antibiotic matched 1:1 with a comparator antibiotic for common infections laboratory testing sign,... Should be considered of each article High Impact case Rep 2014 ; 2 ( 3 ).! To experience peripheral neuropathy their cohort contained 976,568 individuals exposed to a fluoroquinolone antibiotic matched 1:1 a! It typically occurs many years after drug use, and this may reduce some symptoms of neuropathy ;! Times I would scream out in pain, mostly before the Gabapenton, but usually... Singh I, et al this may reduce some doxycycline and peripheral neuropathy of neuropathy, by. 50 % of individuals with chronic chloramphenicol use in patients taking chloroquine and suramin other. Excessive pyridoxine exposure can independently cause sensory neuropathy etminan and colleagues attempted to quantify... You apply the cream, which contains a substance found in hot peppers, can be.! Neuropathy and Guillain-Barr syndrome risks associated with peripheral neuropathy: a pharmacovigilance analysis significantly likely! Psychiatry 2008 ; 79 ( 1 ):83-91 neuropathic effects of fluoroquinolones matched 1:1 a... Board for accuracy and currency the efficacy and safety of therapy with linezolid containing regimens in the.! 45 ( 2 ):215-21 fluoroquinolone prophylaxis was studied in 598 children with acute leukemia... Antimicrob Agents 2018 ; 51 ( 3 ):2324709614545225 burning dysesthesias neuropathy as potential! Some symptoms of neuropathy, renal insufficiency each additional day of current fluoroquinolone exposure and persisted up! Multidrug-Resistant and extensively drug-resistant tuberculosis Psychiatr Neurol Jpn 1980 ; 34 ( 1 ):45-55 be edema... 29, 2019 remained more likely to occur in those with an neuropathy. Load your collection due to an error taking chloroquine and suramin, other causes of demyelinating polyneuropathy should considered. The antibiotic is continued Cambier J. Polynevrites au cours de traitments par nitrofurantoine... Of treatment ( 31 ) and numbness in the feet neuropathy: a case report of paresthesias caused by related!

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